PPIRE08941

Target Protein Information
Protein_Name Chaperone protein DnaK
Protein_Sequence MGKIIGIDLGTTNSCVAIMDGTTPRVLENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFQDEEVQRDVSIMPFKIIAADNGDAWVEVKGQKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKGTGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFDSRLINYLVEEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLTGDVKDVLLLDVTPLSLGIETMGGVMTTLIAKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGERKRAADNKSLGQFNLDGINPAPRGMPQIEVTFDIDADGILHVSAKDKNSGKEQKITIKASSGLNEDEIQKMVRDAEANAEADRKFEELVQTRNQGDHLLHSTRKQVEEAGDKLPADDKTAIESALTALETALKGEDKAAIEAKMQELAQVSQKLMEIAQQQHAQQQTAGADASANNAKDDDVVDAEFEEVKDKK
Organism_Source Escherichia coli O157:H7
Functional_Classification ATPases
Cellular_Localization Cytoplasm
Gene_Names dnaK
UniProt_ID P0A6Z0
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p5A
Peptide_Sequence XLLLSAPRR
Peptide_Length 9
Peptide_SMILES CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification X1=acrylodan
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 982.19
Aliphatic_Index 141.11111
Aromaticity 0.00000
Average_Rotatable_Bonds 3.44444
Charge_at_pH_7 1.99798
Isoelectric_Point 12.50011
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 431.36000
X_logP_energy -3.90866
Interaction Information
Affinity KD=0.05 uM
Affinity_Assay fluorescence titration
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The J-domain of Hsp40 couples ATP hydrolysis to substrate capture in Hsp70.
Release_Year 2003
PMID 12718535
DOI 10.1021/bi027333o