PPIRE08997
Target Protein Information
| Protein_Name | Chemerin-like receptor 1 |
|---|---|
| Protein_Sequence | MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | CMKLR1 |
| UniProt_ID | Q99788 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | natGa-DOTA-ADX-CG34 |
|---|---|
| Peptide_Sequence | YXXGXFaXS |
| Peptide_Length | 9 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)O |
| Chemical_Modification | X2=cyclohexylalanine; X3=hydroxyproline; X5=citrulline; X8=tetrahydroisoquinoline-3-carboxylic acid |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Dota-Adx |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 771.78 |
|---|---|
| Aliphatic_Index | 11.11111 |
| Aromaticity | 0.22222 |
| Average_Rotatable_Bonds | 2.44444 |
| Charge_at_pH_7 | -0.00287 |
| Isoelectric_Point | 6.09320 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 12 |
| Number_of_Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 336.58000 |
| X_logP_energy | -5.36310 |
Interaction Information
| Affinity | IC50=0.32 nM |
|---|---|
| Affinity_Assay | competitive radioligand binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | CMKLR1-targeting peptide tracers for PET/MR imaging of breast cancer. |
| Release_Year | 2019 |
| PMID | 31588246 |
| DOI | 10.7150/thno.34857 |