PPIRE09084
Target Protein Information
| Protein_Name | Complement component 1 Q subcomponent-binding protein, mitochondrial |
|---|---|
| Protein_Sequence | MLPLLRCVPRVLGSSVAGLRAAAPASPFRQLLQPAPRLCTRPFGLLSVRAGSERRPGLLRPRGPCACGCGCGSLHTDGDKAFVDFLSDEIKEERKIQKHKTLPKMSGGWELELNGTEAKLVRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKVEEQEPELTSTPNFVVEVIKNDDGKKALVLDCHYPEDEVGQEDEAESDIFSIREVSFQSTGESEWKDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFVKSQ |
| Organism_Source | Homo sapiens |
| Functional_Classification | cell surface receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | C1QBP |
| UniProt_ID | Q07021 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Syp-1 |
|---|---|
| Peptide_Sequence | XGNKRTRGX |
| Peptide_Length | 9 |
| Peptide_SMILES | C[C@@H](O)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)CN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | X1=selenocysteine; X9=selenocysteine |
| Cyclization_Method | Side chain-side chain cyclization; X1<->X9; other bonds |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 901.98 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.55556 |
| Charge_at_pH_7 | 2.99768 |
| Isoelectric_Point | 12.51648 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 15 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 509.26000 |
| X_logP_energy | -9.28596 |
Interaction Information
| Affinity | KD=18.54 nM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Tumor-targeted liposomal drug delivery mediated by a diseleno bond-stabilized cyclic peptide. |
| Release_Year | 2013 |
| PMID | 23515368 |
| DOI | 10.2147/IJN.S40498 |