PPIRE09104

Target Protein Information
Protein_Name Acetylcholine receptor subunit alpha
Protein_Sequence MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Organism_Source Tetronarce californica
Functional_Classification nicotinic acetylcholine receptors
Cellular_Localization Plasma membrane
Gene_Names CHRNA1
UniProt_ID P02710
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name R8
Peptide_Sequence RRRRRRRRR
Peptide_Length 9
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1423.70
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 5.88889
Charge_at_pH_7 8.99795
Isoelectric_Point 13.40310
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 853.22000
X_logP_energy -11.35387
Interaction Information
Affinity IC50=0.401 uM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Oligoarginine Peptides, a New Family of Nicotinic Acetylcholine Receptor Inhibitors.
Release_Year 2019
PMID 31492697
DOI 10.1124/mol.119.117713