PPIRE09111
Target Protein Information
| Protein_Name | Tyrosine-protein kinase Fyn |
|---|---|
| Protein_Sequence | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL |
| Organism_Source | Homo sapiens |
| Functional_Classification | kinases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | FYN |
| UniProt_ID | P06241 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | 2-hydroxynicotinic acid-Arg-Ala-Leu-Pro-Pro-Leu-Pro-DAP-NH2 |
|---|---|
| Peptide_Sequence | XRALPPLPX |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O |
| Chemical_Modification | X1=2-hydroxynicotinic acid; X9=2,3-diaminopropionic acid |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | 2-Hydroxynicotinoyl |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 877.05 |
|---|---|
| Aliphatic_Index | 97.77778 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.44444 |
| Charge_at_pH_7 | 0.99798 |
| Isoelectric_Point | 10.55000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 10 |
| Topological_Polar_Surface_Area | 331.65000 |
| X_logP_energy | -2.56653 |
Interaction Information
| Affinity | KD=18 uM |
|---|---|
| Affinity_Assay | 19F NMR chemical shift titration |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | 19F NMR studies of solvent exposure and peptide binding to an SH3 domain. |
| Release_Year | 2007 |
| PMID | 17182189 |
| DOI | 10.1016/j.bbagen.2006.10.017 |