PPIRE09119

Target Protein Information
Protein_Name Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease
Protein_Sequence MSANGKISVPEAVVNWLFKVIQPIYNDGRTTFHDSLALLDNFHSLRPRTRVFTHSDGTPQLLLSIYGTISTGEDGSSPHSIPVIMWVPSMYPVKPPFISINLENFDMNTISSSLPIQEYIDSNGWIALPILHCWDPAAMNLIMVVQELMSLLHEPPQDQAPSLPPKPNTQLQQEQNTPPLPPKPKSPHLKPPLPPPPPPQPASNALDLMDMDNTDISPTNHHEMLQNLQTVVNELYREDVDYVADKILTRQTVMQESIARFHEIIAIDKNHLRAVEQAIEQTMHSLNAQIDVLTANRAKVQQFSSTSHVDDEDVNSIAVAKTDGLNQLYNLVAQDYALTDTIECLSRMLHRGTIPLDTFVKQGRELARQQFLVRWHIQRITSPLS
Organism_Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Functional_Classification ESCRT-I complex subunit (UEV-domain scaffold)
Cellular_Localization Cytoplasm
Gene_Names STP22
UniProt_ID P25604
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Vps27-PSDP1
Peptide_Sequence QVPSDPYNY
Peptide_Length 9
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H](N)CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1082.13
Aliphatic_Index 32.22222
Aromaticity 0.22222
Average_Rotatable_Bonds 3.11111
Charge_at_pH_7 -1.00327
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 462.71000
X_logP_energy -4.55040
Interaction Information
Affinity KD=84 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast.
Release_Year 2011
PMID 21505419
DOI 10.1038/emboj.2011.122