PPIRE09144

Target Protein Information
Protein_Name N-lysine methyltransferase KMT5A
Protein_Sequence MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
Organism_Source Homo sapiens
Functional_Classification histone methyltransferases
Cellular_Localization Nucleus
Gene_Names KMT5A
UniProt_ID Q9NQR1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H4 peptide R23E
Peptide_Sequence AKRHRKELRD
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1308.51
Aliphatic_Index 49.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.80000
Charge_at_pH_7 3.09051
Isoelectric_Point 11.55036
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 666.24000
X_logP_energy -6.81939
Interaction Information
Affinity KD=27 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 1ZKK
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase.
Release_Year 2005
PMID 15933070
DOI 10.1101/gad.1318405