PPIRE09150

Target Protein Information
Protein_Name N-lysine methyltransferase KMT5A
Protein_Sequence MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
Organism_Source Homo sapiens
Functional_Classification histone methyltransferases
Cellular_Localization Nucleus
Gene_Names KMT5A
UniProt_ID Q9NQR1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H4 peptide R19K
Peptide_Sequence AKRHRKVLRD
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1278.53
Aliphatic_Index 78.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.60000
Charge_at_pH_7 4.08874
Isoelectric_Point 12.24366
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 628.94000
X_logP_energy -6.02819
Interaction Information
Affinity KD=39 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 1ZKK
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase.
Release_Year 2005
PMID 15933070
DOI 10.1101/gad.1318405