PPIRE09217

Target Protein Information
Protein_Name AH receptor-interacting protein
Protein_Sequence MADIIARLREDGIQKRVIQEGRGELPDFQDGTKATFHYRTLHSDDEGTVLDDSRARGKPMELIIGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAVGKDPLEGQRHCCGVAQMREHSSLGHADLDALQQNPQPLIFHMEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVVEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH
Organism_Source Homo sapiens
Functional_Classification TPR-domain co-chaperones
Cellular_Localization Cytoplasm
Gene_Names AIP
UniProt_ID O00170
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AQSLAEDDVE
Peptide_Sequence AQSLAEDDVE
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1076.08
Aliphatic_Index 88.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.60000
Charge_at_pH_7 -3.99757
Isoelectric_Point 3.29497
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 537.74000
X_logP_energy -6.55980
Interaction Information
Affinity KD=12.3 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4APO
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal Alpha-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.
Release_Year 2012
PMID 23300914
DOI 10.1371/journal.pone.0053339