PPIRE09221

Target Protein Information
Protein_Name TNF receptor-associated factor 4
Protein_Sequence MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names TRAF4
UniProt_ID Q9BUZ4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TGFBR1
Peptide_Sequence ARLTALRIKK
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1169.48
Aliphatic_Index 137.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.20000
Charge_at_pH_7 3.99739
Isoelectric_Point 12.53175
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 521.29000
X_logP_energy -3.89506
Interaction Information
Affinity KD=115.3 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Molecular basis for unique specificity of human TRAF4 for platelets GPIbBeta and GPVI.
Release_Year 2017
PMID 29073066
DOI 10.1073/pnas.1708688114