PPIRE09241

Target Protein Information
Protein_Name Autoimmune regulator
Protein_Sequence MATDAALRRLLRLHRTEIAVAVDSAFPLLHALADHDVVPEDKFQETLHLKEKEGCPQAFHALLSWLLTQDSTAILDFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPPPRLPTKRKASEEARAAAPAALTPRGTASPGSQLKAKPPKKPESSAEQQRLPLGNGIQTMSASVQRAVAMSSGDVPGARGAVEGILIQQVFESGGSKKCIQVGGEFYTPSKFEDSGSGKNKARSSSGPKPLVRAKGAQGAAPGGGEARLGQQGSVPAPLALPSDPQLHQKNEDECAVCRDGGELICCDGCPRAFHLACLSPPLREIPSGTWRCSSCLQATVQEVQPRAEEPRPQEPPVETPLPPGLRSAGEEVRGPPGEPLAGMDTTLVYKHLPAPPSAAPLPGLDSSALHPLLCVGPEGQQNLAPGARCGVCGDGTDVLRCTHCAAAFHWRCHFPAGTSRPGTGLRCRSCSGDVTPAPVEGVLAPSPARLAPGPAKDDTASHEPALHRDDLESLLSEHTFDGILQWAIQSMARPAAPFPS
Organism_Source Homo sapiens
Functional_Classification PHD finger
Cellular_Localization Nucleus
Gene_Names AIRE
UniProt_ID O43918
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3R2me2asK4me0
Peptide_Sequence ARTKQTARKS
Peptide_Length 10
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification R2=asymmetric dimethylarginine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1146.32
Aliphatic_Index 20.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.10000
Charge_at_pH_7 3.99739
Isoelectric_Point 12.53175
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 604.84000
X_logP_energy -9.39476
Interaction Information
Affinity KD=29.4 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2KE1
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation.
Release_Year 2009
PMID 19293276
DOI 10.1093/nar/gkp166