PPIRE09275

Target Protein Information
Protein_Name Protein AF-9
Protein_Sequence MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
Organism_Source Homo sapiens
Functional_Classification acetyllysine reader
Cellular_Localization Nucleus
Gene_Names MLLT3
UniProt_ID P42568
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H3(1-10)K9ac
Peptide_Sequence ARTKQTARXS
Peptide_Length 10
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification X9=N-epsilon-acetyllysine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1075.19
Aliphatic_Index 20.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 2.99768
Isoelectric_Point 12.51648
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 578.82000
X_logP_energy -9.89236
Interaction Information
Affinity KD=3.7 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4TMP
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation.
Release_Year 2014
PMID 25417107
DOI 10.1016/j.cell.2014.09.049