PPIRE09301

Target Protein Information
Protein_Name Tyrosine-protein phosphatase non-receptor type 2
Protein_Sequence MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
Organism_Source Homo sapiens
Functional_Classification protein tyrosine phosphatases
Cellular_Localization Cytoplasm
Gene_Names PTPN2
UniProt_ID P17706
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CF-5
Peptide_Sequence ASGAXAGGSA
Peptide_Length 10
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification X5=di-fluorophosphonomethylphenylalanine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Carboxyfluorescein
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 704.69
Aliphatic_Index 40.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.10000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 365.68000
X_logP_energy -8.64870
Interaction Information
Affinity KD=984.4 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells.
Release_Year 2014
PMID 24387659
DOI 10.1021/cb400903u