PPIRE09302

Target Protein Information
Protein_Name Death-associated inhibitor of apoptosis 1
Protein_Sequence MASVVADLPSYGPIAFDQVDNNTNATQLFKNNINKTRMNDLNREETRLKTFTDWPLDWLDKRQLAQTGMYFTHAGDKVKCFFCGVEIGCWEQEDQPVPEHQRWSPNCPLLRRRTTNNVPINAEALDRILPPISYDICGANDSTLEMREHAYAEGVIPMSQLIQSIGMNAVNAAGSVTGTAAPQPRVTVATHASTATQATGDVQPETCRPSAASGNYFPQYPEYAIETARLRTFEAWPRNLKQKPHQLAEAGFFYTGVGDRVRCFSCGGGLMDWNDNDEPWEQHALWLSQCRFVKLMKGQLYIDTVAAKPVLAEEKEESSSIGGVAVASTQASEEEQQTSLSSEEAVSGDVAPSVAPTAATRIFNKIVEATAVATPSTNSSGSTSIPEEKLCKICYGAEYNTAFLPCGHVVACAKCASSVTKCPLCRKPFTDVMRVYFS
Organism_Source Drosophila melanogaster
Functional_Classification E3 ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names Diap1
UniProt_ID Q24306
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Grim peptide
Peptide_Sequence AVPFFIPDNS
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1106.24
Aliphatic_Index 78.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 2.90000
Charge_at_pH_7 -1.00157
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 408.26000
X_logP_energy -2.67630
Interaction Information
Affinity KD=0.24 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides
Release_Year 2001
PMID 11511363
DOI 10.1016/s1097-2765(01)00282-9