PPIRE09303

Target Protein Information
Protein_Name Death-associated inhibitor of apoptosis 1
Protein_Sequence MASVVADLPSYGPIAFDQVDNNTNATQLFKNNINKTRMNDLNREETRLKTFTDWPLDWLDKRQLAQTGMYFTHAGDKVKCFFCGVEIGCWEQEDQPVPEHQRWSPNCPLLRRRTTNNVPINAEALDRILPPISYDICGANDSTLEMREHAYAEGVIPMSQLIQSIGMNAVNAAGSVTGTAAPQPRVTVATHASTATQATGDVQPETCRPSAASGNYFPQYPEYAIETARLRTFEAWPRNLKQKPHQLAEAGFFYTGVGDRVRCFSCGGGLMDWNDNDEPWEQHALWLSQCRFVKLMKGQLYIDTVAAKPVLAEEKEESSSIGGVAVASTQASEEEQQTSLSSEEAVSGDVAPSVAPTAATRIFNKIVEATAVATPSTNSSGSTSIPEEKLCKICYGAEYNTAFLPCGHVVACAKCASSVTKCPLCRKPFTDVMRVYFS
Organism_Source Drosophila melanogaster
Functional_Classification E3 ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names Diap1
UniProt_ID Q24306
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Hid peptide
Peptide_Sequence AVPFYLPENS
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1136.27
Aliphatic_Index 78.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.00109
Isoelectric_Point 3.84998
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 428.49000
X_logP_energy -2.58060
Interaction Information
Affinity KD=0.04 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides
Release_Year 2001
PMID 11511363
DOI 10.1016/s1097-2765(01)00282-9