PPIRE09311

Target Protein Information
Protein_Name PDCD10 and GCKIII kinases-associated protein 1
Protein_Sequence MGCRCCKIIQSYLFDPVQVPSPGYVNEVNSCKLDEDDTDKLKGKWSSEVLVQKNDPQRQGSKKTESSSRTADPWEPCWPHQGPLPQGDAGGEHHACGVNGIGPAATPQPTGNSSPTQDDRGSWASTANTVPPTQPFLEGGGTRKQDCVLLASEGTQVMRNGDSRAPSEAESFALEVQDHVFQIPAPDYLQHWGPAGDNVDHNEKDCVFKNHTEDESLEGIQPPVGEHGLNTPFSVRRSWDSLNEDVETEVLSICFNEKGPVHAMPVVDSGNRQEDTHGSDGDGDGEIVDEDAAVAEALAALEAATAGEDLDETD
Organism_Source Homo sapiens
Functional_Classification scaffolding proteins
Cellular_Localization Cytoplasm
Gene_Names PGCKA1
UniProt_ID Q8IY42
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name paxillin LD1
Peptide_Sequence DALLADLEST
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1047.13
Aliphatic_Index 137.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 -2.99935
Isoelectric_Point 3.38003
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 477.58000
X_logP_energy -4.87310
Interaction Information
Affinity KD=17 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 3RQE
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Molecular recognition of leucine-aspartate repeat (LD)motifs by the focal adhesion targeting homology domain of cerebral cavernous malformation 3 (CCM3).
Release_Year 2011
PMID 21632544
DOI 10.1074/jbc.M110.211250