PPIRE09378

Target Protein Information
Protein_Name AP-4 complex subunit mu-1
Protein_Sequence MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
Organism_Source Homo sapiens
Functional_Classification adaptor proteins
Cellular_Localization Cytoplasm
Gene_Names AP4M1
UniProt_ID O00189
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name APP ENPTYKFFEQ
Peptide_Sequence ENPTYKFFEQ
Peptide_Length 10
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1302.41
Aliphatic_Index 0.00000
Aromaticity 0.30000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -0.99961
Isoelectric_Point 4.25815
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 543.69000
X_logP_energy -3.91830
Interaction Information
Affinity KD=29.6 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3L81
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
Release_Year 2010
PMID 20230749
DOI 10.1016/j.devcel.2010.01.015