PPIRE09394

Target Protein Information
Protein_Name Protein MEMO1
Protein_Sequence MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH
Organism_Source Homo sapiens
Functional_Classification phosphotyrosine-binding proteins
Cellular_Localization Cytoplasm
Gene_Names MEMO1
UniProt_ID Q9Y316
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FL-pYD10
Peptide_Sequence FDNLYXWDQD
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification X6=phosphotyrosine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fluorescein
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1272.29
Aliphatic_Index 39.00000
Aromaticity 0.30000
Average_Rotatable_Bonds 3.80000
Charge_at_pH_7 -3.00153
Isoelectric_Point 3.33853
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 559.32000
X_logP_energy -4.08100
Interaction Information
Affinity KD=532 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Identification of Phenazine-Based MEMO1 Small-Molecule Inhibitors: Virtual Screening, Fluorescence Polarization Validation, and Inhibition of Breast Cancer Migration.
Release_Year 2020
PMID 33332774
DOI 10.1002/cmdc.202000797