PPIRE09399

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, A alpha chain
Protein_Sequence MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
Organism_Source Homo sapiens
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names HLA-A
UniProt_ID P04439
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name FLPSDC(Fl)FPSV
Peptide_Sequence FLPSDCFPSV
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)O)C(C)C
Chemical_Modification C6=fluorescein
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1111.28
Aliphatic_Index 68.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 2.90000
Charge_at_pH_7 -1.06354
Isoelectric_Point 3.74997
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 385.40000
X_logP_energy -2.64950
Interaction Information
Affinity IC50=147 nM
Affinity_Assay fluorometric size-exclusion HPLC
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title hCXCR1 and hCXCR2 antagonists derived from combinatorial peptide libraries.
Release_Year 1997
PMID None
DOI 10.1016/S0022-1759(96)00087-4