PPIRE09407
Target Protein Information
| Protein_Name | Protein unc-119 homolog A |
|---|---|
| Protein_Sequence | MKVKKGGGGAGTATESAPGPSGQSVAPIPQPPAESESGSESEPDAGPGPRPGPLQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP |
| Organism_Source | Homo sapiens |
| Functional_Classification | Structural proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | UNC119 |
| UniProt_ID | Q13432 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | lauroyl-GAGASAEEKH |
|---|---|
| Peptide_Sequence | GAGASAEEKH |
| Peptide_Length | 10 |
| Peptide_SMILES | C[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Lauroyl |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 955.98 |
|---|---|
| Aliphatic_Index | 30.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.20000 |
| Charge_at_pH_7 | -0.90785 |
| Isoelectric_Point | 5.49308 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 16 |
| Topological_Polar_Surface_Area | 474.75000 |
| X_logP_energy | -7.09930 |
Interaction Information
| Affinity | KD=0.54 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 3RBQ |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | UNC119 is required for G protein trafficking in sensory neurons. |
| Release_Year | 2011 |
| PMID | 21642972 |
| DOI | 10.1038/nn.2835 |