PPIRE09414

Target Protein Information
Protein_Name Importin subunit alpha-1
Protein_Sequence MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF
Organism_Source Mus musculus
Functional_Classification nuclear transport receptors
Cellular_Localization Cytoplasm
Gene_Names Kpna2
UniProt_ID P52293
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PLSCR1 NLS
Peptide_Sequence GKISKHWTGI
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CN)[C@@H](C)CC)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1126.32
Aliphatic_Index 78.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 2.08830
Isoelectric_Point 10.80542
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 462.19000
X_logP_energy -3.56260
Interaction Information
Affinity KD=45.8 nM
Affinity_Assay fluorescence anisotropy
PDB_ID 1Y2A
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha.
Release_Year 2005
PMID 15611084
DOI 10.1074/jbc.M413194200