PPIRE09429

Target Protein Information
Protein_Name Peptidyl-prolyl cis-trans isomerase FKBP8
Protein_Sequence MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQPPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKGQVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
Organism_Source Homo sapiens
Functional_Classification peptidyl-prolyl isomerases
Cellular_Localization Cytoplasm
Gene_Names FKBP8
UniProt_ID Q14318
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name human Hsp70 GSGPTIEEVD peptide
Peptide_Sequence GSGPTIEEVD
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1003.03
Aliphatic_Index 68.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.10000
Charge_at_pH_7 -2.99802
Isoelectric_Point 3.42471
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 468.79000
X_logP_energy -6.19000
Interaction Information
Affinity KD=147 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90.
Release_Year 2017
PMID 28278223
DOI 10.1371/journal.pone.0173543