PPIRE09450

Target Protein Information
Protein_Name Alkaline phosphatase
Protein_Sequence MKQSTIALALLPLLFTPVTKARTPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Organism_Source Escherichia coli (strain K12)
Functional_Classification phosphatases
Cellular_Localization Extracellular
Gene_Names phoA
UniProt_ID P00634
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P1
Peptide_Sequence HATPPKKEAD
Peptide_Length 10
Peptide_SMILES C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1093.20
Aliphatic_Index 20.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.30000
Charge_at_pH_7 0.09052
Isoelectric_Point 7.54876
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 15
Topological_Polar_Surface_Area 483.19000
X_logP_energy -5.24220
Interaction Information
Affinity KD=44 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Development of a universal phosphorylated peptide-binding protein for simultaneous assay of kinases.
Release_Year 2009
PMID 19349157
DOI 10.1016/j.bios.2009.02.020