PPIRE09457

Target Protein Information
Protein_Name Substance-K receptor
Protein_Sequence MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPITKATIAGIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRAVPRHQAHGANLRHLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTRTPSLSRRVNRCHTKETLFMTADMTHSEATNGQVGSPQDVEPAAP
Organism_Source Mesocricetus auratus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names TACR2
UniProt_ID P51144
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Neurokinin A
Peptide_Sequence HKTDSFVGLM
Peptide_Length 10
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1134.32
Aliphatic_Index 68.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 0.08904
Isoelectric_Point 7.54935
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 457.68000
X_logP_energy -3.96660
Interaction Information
Affinity IC50=1 nM
Affinity_Assay filtration binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Evaluation of an 111In-radiolabeled peptide as a targeting and imaging agent for ErbB-2 receptor expressing breast carcinomas.
Release_Year 1992
PMID None
DOI 10.1021/jm00057a028