PPIRE09497

Target Protein Information
Protein_Name Protein spinster homolog 1
Protein_Sequence MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI
Organism_Source Homo sapiens
Functional_Classification histone methylation readers
Cellular_Localization Nucleus
Gene_Names SPNS1
UniProt_ID Q9H2V7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name H4K20me3 peptide
Peptide_Sequence KRHRKVLRDN
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)O
Chemical_Modification K5=trimethylation
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1321.55
Aliphatic_Index 68.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.80000
Charge_at_pH_7 4.08874
Isoelectric_Point 12.24366
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 25
Topological_Polar_Surface_Area 672.03000
X_logP_energy -7.17269
Interaction Information
Affinity KD=0.8 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5Y5W
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail.
Release_Year 2018
PMID 30381828
DOI 10.1002/1873-3468.13281