PPIRE09502

Target Protein Information
Protein_Name RNA-binding protein 39
Protein_Sequence MADDIDIEAMLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLLVPSRR
Organism_Source Homo sapiens
Functional_Classification splicing factor
Cellular_Localization Nucleus
Gene_Names RBM39
UniProt_ID Q14498
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SF3b155 ULM5
Peptide_Sequence KRKSRWDETP
Peptide_Length 10
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1302.46
Aliphatic_Index 0.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.30000
Charge_at_pH_7 1.99961
Isoelectric_Point 10.77375
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 623.12000
X_logP_energy -6.51116
Interaction Information
Affinity KD=2.4 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 4OZ1
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Cancer-relevant splicing factor CAPERAlpha engages the essential splicing factor SF3b155 in a specific ternary complex.
Release_Year 2014
PMID 24795046
DOI 10.1074/jbc.M114.558825