PPIRE09513

Target Protein Information
Protein_Name Melanocyte-stimulating hormone receptor
Protein_Sequence MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names MC1R
UniProt_ID Q01726
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 13
Peptide_Sequence LEHFRWMKPI
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1356.65
Aliphatic_Index 78.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 4.20000
Charge_at_pH_7 1.09037
Isoelectric_Point 9.69703
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 486.12000
X_logP_energy 0.30257
Interaction Information
Affinity EC50=14 nM
Affinity_Assay luciferase reporter assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Isolation and characterization of antagonist and agonist peptides to the human melanocortin 1 receptor.
Release_Year 2005
PMID 15893405
DOI 10.1016/j.peptides.2005.04.002