PPIRE09533

Target Protein Information
Protein_Name Syntaxin-binding protein 1
Protein_Sequence MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
Organism_Source Rattus norvegicus
Functional_Classification Sec1/Munc18 family
Cellular_Localization Cytoplasm
Gene_Names Stxbp1
UniProt_ID P61765
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Sx1 N-peptide
Peptide_Sequence MKDRTQELRT
Peptide_Length 10
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1277.46
Aliphatic_Index 39.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 4.60000
Charge_at_pH_7 0.99990
Isoelectric_Point 9.69016
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 23
Topological_Polar_Surface_Area 633.19000
X_logP_energy -7.41716
Interaction Information
Affinity KD=58 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3C98
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.
Release_Year 2011
PMID 21193638
DOI 10.1073/pnas.0914906108