PPIRE09542

Target Protein Information
Protein_Name Nuclear fusion protein BIK1
Protein_Sequence MDRYQRKIGCFIQIPNLGRGQLKYVGPVDTKAGMFAGVDLLANIGKNDGSFMGKKYFQTEYPQSGLFIQLQKVASLIEKASISQTSRRTTMEPLSIPKNRSIVRLTNQFSPMDDPKSPTPMRSFRITSRHSGNQQSMDQEASDHHQQQEFGYDNREDRMEVDSILSSDRKANHNTTSDWKPDNGHMNDLNSSEVTIELREAQLTIEKLQRKQLHYKRLLDDQRMVLEEVQPTFDRYEATIQEREKEIDHLKQQLELERRQQAKQKQFFDAENEQLLAVVSQLHEEIKENEERNLSHNQPTGANEDVELLKKQLEQLRNIEDQFELHKTKWAKEREQLKMHNDSLSKEYQNLSKELFLTKPQDSSSEEVASLTKKLEEANEKIKQLEQAQAQTAVESLPIFDPPAPVDTTAGRQQWCEHCDTMGHNTAECPHHNPDNQQFF
Organism_Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Functional_Classification microtubule plus-end tracking proteins
Cellular_Localization Cytoplasm
Gene_Names BIK1
UniProt_ID P11709
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ETF peptide
Peptide_Sequence NNLIIDEETF
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1207.30
Aliphatic_Index 117.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -2.99802
Isoelectric_Point 3.42471
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 543.53000
X_logP_energy -4.52160
Interaction Information
Affinity KD=5.6 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 6FC6
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure-Function Relationship of the Bik1-Bim1 Complex.
Release_Year 2018
PMID 29576319
DOI 10.1016/j.str.2018.03.003