PPIRE09556

Target Protein Information
Protein_Name Proteasomal ubiquitin receptor ADRM1
Protein_Sequence MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
Organism_Source Homo sapiens
Functional_Classification ubiquitin receptor
Cellular_Localization Cytoplasm
Gene_Names ADRM1
UniProt_ID Q16186
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name hRpn2(944-953)
Peptide_Sequence PPEPFEYIDD
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1221.29
Aliphatic_Index 39.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.30000
Charge_at_pH_7 -3.99842
Isoelectric_Point 3.29497
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 463.08000
X_logP_energy -1.88530
Interaction Information
Affinity KD=1.96 mM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 2NBK
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.
Release_Year 2017
PMID 28598414
DOI 10.1038/ncomms15540