PPIRE09566

Target Protein Information
Protein_Name Src substrate cortactin
Protein_Sequence MWKASAGHAVSITQDDGGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDRSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSSAVGFDYKERLAKHESQQDYAKGFGGKYGVQKDRMDKNASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKKQTPPASPSPQPIEDRPPSSPIYEDAAPFKAEPSYRGSEPEPEYSIEAAGIPEAGSQQGLTYTSEPVYETTEAPGHYQAEDDTYDGYESDLGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
Organism_Source Mus musculus
Functional_Classification SH3 domain
Cellular_Localization Cytoplasm
Gene_Names Cttn
UniProt_ID Q60598
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name F5
Peptide_Sequence PXXLXPKXKF
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification X2=4(R)-4-fluoroproline; X3=4(R)-4-fluoroproline; X5=4(R)-4-fluoroproline; X8=4(R)-4-fluoroproline
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 957.14
Aliphatic_Index 39.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 1.99739
Isoelectric_Point 10.80538
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 354.48000
X_logP_energy -3.23520
Interaction Information
Affinity KD=6.6 uM
Affinity_Assay circular dichroism spectroscopy
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The impact of either 4-R-hydroxyproline or 4-R-fluoroproline on the conformation and SH3m-cort binding of HPK1 proline-rich peptide.
Release_Year 2013
PMID 22976002
DOI 10.1007/s00726-012-1383-y