PPIRE09584

Target Protein Information
Protein_Name Renin receptor
Protein_Sequence MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD
Organism_Source Homo sapiens
Functional_Classification single-pass transmembrane receptor
Cellular_Localization Plasma membrane
Gene_Names ATP6AP2
UniProt_ID O75787
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Decoy peptide
Peptide_Sequence RIFLKRMPSI
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1260.61
Aliphatic_Index 117.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.20000
Charge_at_pH_7 2.99768
Isoelectric_Point 12.51648
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 486.48000
X_logP_energy -1.95036
Interaction Information
Affinity KD=3.5 nM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Decoy peptide' region (RIFLKRMPSI)of prorenin prosegment plays a crucial role in prorenin binding to the (pro)renin receptor.
Release_Year 2009
PMID 19513539
DOI 10.3892/ijmm_00000210