PPIRE09650

Target Protein Information
Protein_Name Beta sliding clamp
Protein_Sequence MKFTVEREHLLKPLQQVSGPLGGRPTLPILGNLLLQVADGTLSLTGTDLEMEMVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRMLDGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYVVMPMRL
Organism_Source Escherichia coli (strain K12)
Functional_Classification processivity factor
Cellular_Localization Cytoplasm
Gene_Names dnaN
UniProt_ID P0A988
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name E. coli Pol II C-terminal 10-mer
Peptide_Sequence TLMTGQLGLF
Peptide_Length 10
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Tamn
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1080.31
Aliphatic_Index 117.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 408.77000
X_logP_energy -2.81450
Interaction Information
Affinity KD=1.7 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3D1E
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.
Release_Year 2008
PMID 18678908
DOI 10.1073/pnas.0804754105