PPIRE09659

Target Protein Information
Protein_Name Killer cell immunoglobulin-like receptor 3DL1
Protein_Sequence MSLMVVSMACVGLFLVQRAGPHMGGQDKPFLSAWPSAVVPRGGHVTLRCHYRHRFNNFMLYKEDRIHIPIFHGRIFQESFNMSPVTTAHAGNYTCRGSHPHSPTGWSAPSNPVVIMVTGNHRKPSLLAHPGPLVKSGERVILQCWSDIMFEHFFLHKEGISKDPSRLVGQIHDGVSKANFSIGPMMLALAGTYRCYGSVTHTPYQLSAPSDPLDIVVTGPYEKPSLSAQPGPKVQAGESVTLSCSSRSSYDMYHLSREGGAHERRLPAVRKVNRTFQADFPLGPATHGGTYRCFGSFRHSPYEWSDPSDPLLVSVTGNPSSSWPSPTEPSSKSGNPRHLHILIGTSVVIILFILLLFFLLHLWCSNKKNAAVMDQEPAGNRTANSEDSDEQDPEEVTYAQLDHCVFTQRKITRPSQRPKTPPTDTILYTELPNAKPRSKVVSCP
Organism_Source Homo sapiens
Functional_Classification Killer cell immunoglobulin-like receptors
Cellular_Localization Plasma membrane
Gene_Names KIR3DL1
UniProt_ID P43629
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TW10
Peptide_Sequence TSTLQEQIGW
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1162.26
Aliphatic_Index 78.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.70000
Charge_at_pH_7 -1.00024
Isoelectric_Point 3.84998
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 18
Topological_Polar_Surface_Area 525.18000
X_logP_energy -5.64120
Interaction Information
Affinity KD=62.1 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 5T6Z
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.
Release_Year 2017
PMID 28218747
DOI 10.1038/nsmb.3381