PPIRE09692
Target Protein Information
| Protein_Name | ATP-dependent Clp protease adapter protein ClpS |
|---|---|
| Protein_Sequence | MGKTNDWLDFDQLAEEKVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCTLEKA |
| Organism_Source | Escherichia coli (strain SE11) |
| Functional_Classification | adaptor proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | clpS |
| UniProt_ID | B6I8V2 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Wpep |
|---|---|
| Peptide_Sequence | WLTMITDSLA |
| Peptide_Length | 10 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1150.36 |
|---|---|
| Aliphatic_Index | 127.00000 |
| Aromaticity | 0.10000 |
| Average_Rotatable_Bonds | 3.50000 |
| Charge_at_pH_7 | -1.00157 |
| Isoelectric_Point | 3.74999 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 16 |
| Topological_Polar_Surface_Area | 439.00000 |
| X_logP_energy | -2.37460 |
Interaction Information
| Affinity | KD=8.1 uM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS. |
| Release_Year | 2009 |
| PMID | 19373253 |
| DOI | 10.1038/embor.2009.62 |