PPIRE09695
Target Protein Information
| Protein_Name | Tumor necrosis factor ligand superfamily member 13B |
|---|---|
| Protein_Sequence | MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL |
| Organism_Source | Homo sapiens |
| Functional_Classification | TNF family |
| Cellular_Localization | Extracellular |
| Gene_Names | TNFSF13B |
| UniProt_ID | Q9Y275 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | DX-876 |
|---|---|
| Peptide_Sequence | WYDPLTKLWL |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1334.58 |
|---|---|
| Aliphatic_Index | 117.00000 |
| Aromaticity | 0.30000 |
| Average_Rotatable_Bonds | 3.70000 |
| Charge_at_pH_7 | -0.00271 |
| Isoelectric_Point | 6.33059 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 15 |
| Number_of_Hydrogen_Bond_Donors | 16 |
| Topological_Polar_Surface_Area | 451.79000 |
| X_logP_energy | 1.78680 |
Interaction Information
| Affinity | KD=171 nM |
|---|---|
| Affinity_Assay | fluorescence anisotropy |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Discovery of high-affinity peptide binders to BLyS by phage display. |
| Release_Year | 2005 |
| PMID | 15382264 |
| DOI | 10.1002/jmr.722 |