PPIRE09703

Target Protein Information
Protein_Name D(2)dopamine receptor
Protein_Sequence MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
Organism_Source Rattus norvegicus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Drd2
UniProt_ID P61169
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LH/FSH-RH
Peptide_Sequence XHWSYGLRPG
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Chemical_Modification X1=pyroglutamate
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Pyroglutamate
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1129.24
Aliphatic_Index 39.00000
Aromaticity 0.20000
Average_Rotatable_Bonds 3.10000
Charge_at_pH_7 1.08804
Isoelectric_Point 9.35118
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 463.26000
X_logP_energy -3.89833
Interaction Information
Affinity IC50=100 uM
Affinity_Assay radioligand binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Binding of opiates and endogenous opioid peptides to neuroleptic receptor sites in the corpus striatum.
Release_Year 1978
PMID 205747
DOI 10.1016/0024-3205(78)90360-0