PPIRE09719

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, A alpha chain
Protein_Sequence MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
Organism_Source Homo sapiens
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names HLA-A
UniProt_ID P04439
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Mart-1(26-35)
Peptide_Sequence XXAGIGILTV
Peptide_Length 10
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)CN)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O)[C@@H](C)CC
Chemical_Modification X1=S-methyl-L-cysteine; X2=norvaline
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 857.02
Aliphatic_Index 156.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.70000
Charge_at_pH_7 -0.00202
Isoelectric_Point 6.10000
Number_of_Hydrogen_Bond_Acceptors 12
Number_of_Hydrogen_Bond_Donors 12
Topological_Polar_Surface_Area 345.45000
X_logP_energy -3.51790
Interaction Information
Affinity IC50=0.97 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Altered peptide ligands revisited: vaccine design through chemically modified HLA-A2-restricted T cell epitopes.
Release_Year 2014
PMID 25311806
DOI 10.4049/jimmunol.1400800