PPIRE09733

Target Protein Information
Protein_Name Kappa-type opioid receptor
Protein_Sequence MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
Organism_Source Mus musculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Oprk1
UniProt_ID P33534
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name a-Neo-endorphin
Peptide_Sequence YGGFLRKYPG
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1157.34
Aliphatic_Index 39.00000
Aromaticity 0.30000
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 1.99599
Isoelectric_Point 10.00862
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 16
Topological_Polar_Surface_Area 444.81000
X_logP_energy -2.26043
Interaction Information
Affinity IC50=50 nM
Affinity_Assay in vitro bioassay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title [Leu5]enkephalin containing peptides derived from a common precursor: evaluation of opioid activity in in vitro bioassays.
Release_Year 1984
PMID 6327333
DOI 10.1016/0014-2999(84)90287-5