PPIRE09824
Target Protein Information
| Protein_Name | Growth factor receptor-bound protein 2 |
|---|---|
| Protein_Sequence | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV |
| Organism_Source | Homo sapiens |
| Functional_Classification | SH2 domains |
| Cellular_Localization | Cytoplasm |
| Gene_Names | GRB2 |
| UniProt_ID | P62993 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | G1TE(Gla2) |
|---|---|
| Peptide_Sequence | XLYENVGMYC |
| Peptide_Length | 10 |
| Peptide_SMILES | CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | X1=c-carboxyglutamic acid |
| Cyclization_Method | Main chain-side chain cyclization; N1<->C10; thioether bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Chloroacetyl |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1148.31 |
|---|---|
| Aliphatic_Index | 68.00000 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.50000 |
| Charge_at_pH_7 | -1.06392 |
| Isoelectric_Point | 3.84996 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 16 |
| Topological_Polar_Surface_Area | 446.07000 |
| X_logP_energy | -2.95390 |
Interaction Information
| Affinity | KD=0.77 uM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | None |
| Type | antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain. |
| Release_Year | 2003 |
| PMID | 14521914 |
| DOI | 10.1016/j.bbrc.2003.09.022 |