PPIRE09836

Target Protein Information
Protein_Name Histone-lysine N-methyltransferase SETD7
Protein_Sequence MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
Organism_Source Homo sapiens
Functional_Classification lysine methyltransferases
Cellular_Localization Nucleus
Gene_Names SETD7
UniProt_ID Q8WTS6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TAF10-K189me2
Peptide_Sequence SKSXDRKYTL
Peptide_Length 10
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)O
Chemical_Modification X4=dimethylation
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1154.29
Aliphatic_Index 39.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 1.99699
Isoelectric_Point 10.24366
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 557.38000
X_logP_energy -7.25133
Interaction Information
Affinity KD=70 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3M56
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
Release_Year 2010
PMID 20675860
DOI 10.1074/jbc.M110.114587