PPIRE09915

Target Protein Information
Protein_Name WD repeat-containing protein 5
Protein_Sequence MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
Organism_Source Homo sapiens
Functional_Classification WD40 repeat proteins
Cellular_Localization Nucleus
Gene_Names WDR5
UniProt_ID P61964
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name N2H3 T3V
Peptide_Sequence ARVKQTARKSY
Peptide_Length 11
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1307.52
Aliphatic_Index 44.54545
Aromaticity 0.09091
Average_Rotatable_Bonds 4.09091
Charge_at_pH_7 3.99654
Isoelectric_Point 11.67668
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 633.94000
X_logP_energy -7.68646
Interaction Information
Affinity KD=0.1 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3PSL
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.
Release_Year 2011
PMID 21135039
DOI 10.1096/fj.10-171959