PPIRE09933

Target Protein Information
Protein_Name Importin subunit alpha-1
Protein_Sequence MSTNENANLPAARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFNF
Organism_Source Mus musculus
Functional_Classification nuclear transport receptors
Cellular_Localization Cytoplasm
Gene_Names Kpna2
UniProt_ID P52293
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Importin-alpha autoinhibitory peptide
Peptide_Sequence DEQMLKRRNVS
Peptide_Length 11
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1375.57
Aliphatic_Index 61.81818
Aromaticity 0.00000
Average_Rotatable_Bonds 4.54545
Charge_at_pH_7 0.99990
Isoelectric_Point 9.69016
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 685.15000
X_logP_energy -8.17026
Interaction Information
Affinity KD=4 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 1IQ1
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Biophysical characterization of interactions involving importin-alpha during nuclear import.
Release_Year 2001
PMID 11448961
DOI 10.1074/jbc.M103531200