PPIRE09965

Target Protein Information
Protein_Name Mitochondrial import receptor subunit TOM20 homolog
Protein_Sequence MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGDYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE
Organism_Source Rattus norvegicus
Functional_Classification mitochondrial protein import receptor
Cellular_Localization Mitochondrion
Gene_Names Tomm20
UniProt_ID Q62760
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name linear pALDH(cxxC)
Peptide_Sequence GcRLCRLLSYA
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)CN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1254.53
Aliphatic_Index 115.45455
Aromaticity 0.09091
Average_Rotatable_Bonds 3.63636
Charge_at_pH_7 1.87318
Isoelectric_Point 8.80386
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 518.58000
X_logP_energy -4.63736
Interaction Information
Affinity KD=160 uM
Affinity_Assay NMR titration
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Crystallographic snapshots of Tom20-mitochondrial presequence interactions with disulfide-stabilized peptides.
Release_Year 2011
PMID 21591667
DOI 10.1021/bi200470x