PPIRE09997

Target Protein Information
Protein_Name HLA class I histocompatibility antigen, B alpha chain
Protein_Sequence MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA
Organism_Source Homo sapiens
Functional_Classification MHC class I
Cellular_Localization Plasma membrane
Gene_Names HLA-B
UniProt_ID P01889
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HPVG
Peptide_Sequence HPVGEADYFEY
Peptide_Length 11
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1326.38
Aliphatic_Index 35.45455
Aromaticity 0.27273
Average_Rotatable_Bonds 3.36364
Charge_at_pH_7 -2.90881
Isoelectric_Point 3.92633
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 526.57000
X_logP_energy -2.63080
Interaction Information
Affinity KD=93.2 uM
Affinity_Assay Surface plasmon resonance
PDB_ID 4PRI
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism.
Release_Year 2014
PMID 24759101
DOI 10.1074/jbc.M114.563502