PPIRE10011
Target Protein Information
| Protein_Name | Rhodopsin |
|---|---|
| Protein_Sequence | MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA |
| Organism_Source | Bos taurus |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | RHO |
| UniProt_ID | P02699 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | GtaCT-HA |
|---|---|
| Peptide_Sequence | ILENLKDCGLF |
| Peptide_Length | 11 |
| Peptide_SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1264.50 |
|---|---|
| Aliphatic_Index | 141.81818 |
| Aromaticity | 0.09091 |
| Average_Rotatable_Bonds | 3.90909 |
| Charge_at_pH_7 | -1.06206 |
| Isoelectric_Point | 4.18437 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 498.03000 |
| X_logP_energy | -2.42150 |
Interaction Information
| Affinity | KD=320 uM |
|---|---|
| Affinity_Assay | competitive radioligand binding assay |
| PDB_ID | 3DQB |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Crystal structure of a common GPCR-binding interface for G protein and arrestin. |
| Release_Year | 2014 |
| PMID | 25205354 |
| DOI | 10.1038/ncomms5801 |