PPIRE10014

Target Protein Information
Protein_Name Vitamin K-dependent protein C
Protein_Sequence MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
Organism_Source Homo sapiens
Functional_Classification serine protease
Cellular_Localization Extracellular
Gene_Names PROC
UniProt_ID P04070
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ZAP.14 W7A
Peptide_Sequence IVGGYPAWMDV
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1207.41
Aliphatic_Index 97.27273
Aromaticity 0.18182
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.00242
Isoelectric_Point 3.74999
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 418.85000
X_logP_energy -0.70660
Interaction Information
Affinity EC50=830 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Research Articles
Title An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Release_Year 2014
PMID 24859116
DOI 10.1038/nchembio.1533