PPIRE10058

Target Protein Information
Protein_Name TNF receptor-associated factor 4
Protein_Sequence MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
Organism_Source Homo sapiens
Functional_Classification E3 ubiquitin ligases
Cellular_Localization Cytoplasm
Gene_Names TRAF4
UniProt_ID Q9BUZ4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GPVI
Peptide_Sequence KRLRHRGRAVQ
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1376.63
Aliphatic_Index 70.90909
Aromaticity 0.00000
Average_Rotatable_Bonds 4.45455
Charge_at_pH_7 5.08859
Isoelectric_Point 12.98095
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 699.71000
X_logP_energy -7.98692
Interaction Information
Affinity KD=35 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Molecular basis for unique specificity of human TRAF4 for platelets GPIbBeta and GPVI.
Release_Year 2017
PMID 29073066
DOI 10.1073/pnas.1708688114