PPIRE10062

Target Protein Information
Protein_Name HLA class II histocompatibility antigen, DRB1 beta chain
Protein_Sequence MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
Organism_Source Homo sapiens
Functional_Classification MHC class II
Cellular_Localization Plasma membrane
Gene_Names HLA-DRB1
UniProt_ID P01911
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Fl-HSP65(3/13)
Peptide_Sequence KTIAYDEEARR
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Fluorescein-Ahx
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1351.48
Aliphatic_Index 53.63636
Aromaticity 0.09091
Average_Rotatable_Bonds 4.18182
Charge_at_pH_7 0.00083
Isoelectric_Point 6.57794
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 24
Topological_Polar_Surface_Area 656.50000
X_logP_energy -6.47886
Interaction Information
Affinity IC50=102 nM
Affinity_Assay fluorometric size-exclusion HPLC
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Conjugates of a novel 7-substituted camptothecin with RGD-peptides as alpha(v)beta? integrin ligands: An approach to tumor-targeted therapy.
Release_Year 1997
PMID None
DOI 10.1016/S0022-1759(96)00087-4