PPIRE10093

Target Protein Information
Protein_Name Cyclin-dependent kinase 2
Protein_Sequence MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Organism_Source Homo sapiens
Functional_Classification protein kinases
Cellular_Localization Nucleus
Gene_Names CDK2
UniProt_ID P24941
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name pRb(residues 870-878)
Peptide_Sequence PPKPLKKLRFD
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1338.66
Aliphatic_Index 70.90909
Aromaticity 0.09091
Average_Rotatable_Bonds 3.90909
Charge_at_pH_7 2.99754
Isoelectric_Point 11.07952
Number_of_Hydrogen_Bond_Acceptors 17
Number_of_Hydrogen_Bond_Donors 17
Topological_Polar_Surface_Area 500.01000
X_logP_energy -1.85673
Interaction Information
Affinity KD=1.8 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 1H25
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A.
Release_Year 2002
PMID 12501191
DOI 10.1021/bi0268910